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Genes and Alzheimer’s: the key to the mystery?
13 mars 2025
#Alzheimer #Genetics #Neurodegeneration #PrecisionMedicine #GWAS #MultiAncestral
Alzheimer’s disease (AD) is the most common form of dementia, affecting millions worldwide. It is characterized by a progressive decline in cognitive functions, impacting memory, language, and spatial orientation. While environmental factors and lifestyle contribute to its onset, genetics play a crucial role in disease predisposition. It is estimated that 70% to 80% of the risk of developing AD is hereditary, highlighting the importance of identifying the genes involved to better understand the pathology and develop targeted therapeutic approaches.
Alzheimer’s disease (AD) is the most common form of dementia, affecting millions worldwide. It is characterized by a progressive decline in cognitive functions, impacting memory, language, and spatial orientation. While environmental factors and lifestyle contribute to its onset, genetics play a crucial role in disease predisposition. It is estimated that 70% to 80% of the risk of developing AD is hereditary, highlighting the importance of identifying the genes involved to better understand the pathology and develop targeted therapeutic approaches.
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Scientific reference
Willett, J. D. S., et al. (2025). Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses. Alzheimer's & dementia : the journal of the Alzheimer's Association, 21(2), e14592
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