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GPCRs: thinking beyond the membrane
10 février 2026
By Ana Espino | Published on February 10, 2026 | 3 min readG protein-coupled receptors (GPCRs) are central to cellular signaling. They regulate key physiological functions—cardiovascular, neurological, immune—and account for nearly one-third of all current drug targets. Traditionally, GPCRs were thought to function exclusively at the plasma membrane, where they initiate rapid and transient intrace
By Ana Espino | Published on February 10, 2026 | 3 min read
G protein-coupled receptors (GPCRs) are central to cellular signaling. They regulate key physiological functions—cardiovascular, neurological, immune—and account for nearly one-third of all current drug targets. Traditionally, GPCRs were thought to function exclusively at the plasma membrane, where they initiate rapid and transient intracellular signaling via G proteins and β-arrestins.
G protein-coupled receptors (GPCRs) are central to cellular signaling. They regulate key physiological functions—cardiovascular, neurological, immune—and account for nearly one-third of all current drug targets. Traditionally, GPCRs were thought to function exclusively at the plasma membrane, where they initiate rapid and transient intracellular signaling via G proteins and β-arrestins.
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Scientific reference
Bock A, et al. Chemical biology approaches to resolve the subcellular GPCR signaling landscape. Nat Chem Biol. 2025 Aug;21(8):1148-1159
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