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Influenza: a recombinant vaccine improves immune response in patients with severe obesity
16 avril 2026
By Elodie Vaz | Published on April 16, 2026 | 3 min readA major viral infection, seasonal influenza is responsible each year for severe complications and hospitalizations, particularly among vulnerable populations. Among them, people living with severe obesity (defined as a BMI ≥ 35 kg/m²) represent a high-risk group that remains insufficiently characterized in vaccine trials. In France, this cond
By Elodie Vaz | Published on April 16, 2026 | 3 min read
A major viral infection, seasonal influenza is responsible each year for severe complications and hospitalizations, particularly among vulnerable populations. Among them, people living with severe obesity (defined as a BMI ≥ 35 kg/m²) represent a high-risk group that remains insufficiently characterized in vaccine trials.
In France, this condition affects around 6% of the adult population, i.e., more than three million individuals. Obesity is associated with an increased risk of severe influenza, partly due to chronic inflammation and alterations of the immune system. Several studies point to a reduced or less durable vaccine response in this population. Antibody titers measured after vaccination, particularly by hemagglutination inhibition (HAI), are generally correlated with the level of protection, although this relationship remains imperfect.
A major viral infection, seasonal influenza is responsible each year for severe complications and hospitalizations, particularly among vulnerable populations. Among them, people living with severe obesity (defined as a BMI ≥ 35 kg/m²) represent a high-risk group that remains insufficiently characterized in vaccine trials.
In France, this condition affects around 6% of the adult population, i.e., more than three million individuals. Obesity is associated with an increased risk of severe influenza, partly due to chronic inflammation and alterations of the immune system. Several studies point to a reduced or less durable vaccine response in this population. Antibody titers measured after vaccination, particularly by hemagglutination inhibition (HAI), are generally correlated with the level of protection, although this relationship remains imperfect.
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Scientific reference
Recombinant vs Standard Influenza Vaccine in Adults With Severe Obesity: A Randomized Clinical Trial
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