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HDL: an ally going off track?
2 décembre 2025
By Ana Espino | Published on December 2nd, 2025 | 3 min readChronic HIV infection, even when well controlled by antiretroviral therapy, is associated with an increased cardiometabolic risk, including higher rates of cardiovascular events, hypertension, insulin resistance, and dyslipidemia. This elevated risk cannot be explained solely by traditional factors, but also by persistent immunometabolic
By Ana Espino | Published on December 2nd, 2025 | 3 min read
Chronic HIV infection, even when well controlled by antiretroviral therapy, is associated with an increased cardiometabolic risk, including higher rates of cardiovascular events, hypertension, insulin resistance, and dyslipidemia. This elevated risk cannot be explained solely by traditional factors, but also by persistent immunometabolic disturbances linked to the chronic low-grade inflammation characteristic of HIV.
Chronic HIV infection, even when well controlled by antiretroviral therapy, is associated with an increased cardiometabolic risk, including higher rates of cardiovascular events, hypertension, insulin resistance, and dyslipidemia. This elevated risk cannot be explained solely by traditional factors, but also by persistent immunometabolic disturbances linked to the chronic low-grade inflammation characteristic of HIV.
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Scientific reference
Markakis, K., et al. (2025). HDL dysfunction: a role in the pathogenesis of cardiometabolic syndrome in chronic HIV infection?. Metabolism: clinical and experimental, 175, 156432. Advance online publication
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