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Chronic myelomonocytic leukemia: at the molecular roots of inflammation
22 septembre 2025
By Lila Rouland | Published September 22, 2025 | 3 min read
#Hematology #ChronicLymphocyticLeukemia
Chronic myelomonocytic leukemia (CMML) is a rare clonal hematologic disorder that lies at the crossroads between myelodysplastic syndromes and myeloproliferative neoplasms. It occurs mainly in older adults (median age >70 years) and is characterized by persistent monocytosis and a high risk (15–20% at 5 years) of transformation into acute myeloid leukemia (AML). Clinically, two forms are distinguished:
#Hematology #ChronicLymphocyticLeukemia
Chronic myelomonocytic leukemia (CMML) is a rare clonal hematologic disorder that lies at the crossroads between myelodysplastic syndromes and myeloproliferative neoplasms. It occurs mainly in older adults (median age >70 years) and is characterized by persistent monocytosis and a high risk (15–20% at 5 years) of transformation into acute myeloid leukemia (AML). Clinically, two forms are distinguished:
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Scientific reference
Marando L., Csizmar C.M., Patnaik M.M. (2025). Chronic myelomonocytic leukemia: molecular pathogenesis and therapeutic innovations. Haematologica, 110(1), 22–36
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