Vaginal microbiome: a cause of miscarriage ?

By Ana Espino | Published on February 18, 2026 | 3 min read

 
Recurrent pregnancy loss (RPL) affects approximately 1–2% of women of reproductive age and represents a major issue in gynecology and obstetrics. It is defined as the occurrence of at least two consecutive pregnancy losses before 20 weeks of gestation. Although certain causes have been identified (chromosomal abnormalities, coagulation disorders, immunological factors), in nearly 50% of cases no clear triggering factor is found, which considerably complicates management.