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Obesity and heart failure: weight loss may restore heart muscle contractility
30 avril 2026
By Elodie Vaz | Published on April 30, 2026 | 4 min readLong described as a disease of ventricular stiffness, heart failure with preserved ejection fraction (HFpEF) may, in patients with severe obesity, involve a distinct mechanism: an intrinsic impairment of heart muscle contraction. This is the finding of a study conducted by researchers at Johns Hopkins Medicine and published on April 23 in *Sc
By Elodie Vaz | Published on April 30,
2026 | 4 min read
Long described as a disease of ventricular stiffness, heart failure with preserved ejection fraction (HFpEF) may, in patients with severe obesity, involve a distinct mechanism: an intrinsic impairment of heart muscle contraction. This is the finding of a study conducted by researchers at Johns Hopkins Medicine and published on April 23 in *Science*. The work shows that cardiac muscle cells in these patients develop marked contractile weakness, which is partially reversible after significant weight loss.
Long described as a disease of ventricular stiffness, heart failure with preserved ejection fraction (HFpEF) may, in patients with severe obesity, involve a distinct mechanism: an intrinsic impairment of heart muscle contraction. This is the finding of a study conducted by researchers at Johns Hopkins Medicine and published on April 23 in *Science*. The work shows that cardiac muscle cells in these patients develop marked contractile weakness, which is partially reversible after significant weight loss.
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Scientific reference
L’obésité sévère chez l’HFpEF humaine modifie la fonction et l’organisation des protéines contractiles
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