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Pancreas + HCV: Risky gamble or new paradigm?
30 juillet 2025
By Ana Espino | Published on July 30, 2025 | 2 min read
#HCV #Hepatitis #Pancreas
Pancreatic transplantation remains an effective solution for patients with severe type 1 diabetes, but the number of available grafts is still insufficient. In response to this shortage, grafts from donors infected with the hepatitis C virus (HCV) represent an underutilized resource. Historically, transmission of the virus to seronegative recipients (D+/R−) was prohibitive due to infectious risks and the limitations of treatments available at the time (interferon ± ribavirin). The introduction of direct-acting antivirals (DAAs), effective across all genotypes and well tolerated, has changed this perception. In liver and kidney transplants, the outcomes of D+/R− grafts under DAA treatment are very encouraging. However, data on D+/R− pancreatic transplantation remain scarce.
#HCV #Hepatitis #Pancreas
Pancreatic transplantation remains an effective solution for patients with severe type 1 diabetes, but the number of available grafts is still insufficient. In response to this shortage, grafts from donors infected with the hepatitis C virus (HCV) represent an underutilized resource. Historically, transmission of the virus to seronegative recipients (D+/R−) was prohibitive due to infectious risks and the limitations of treatments available at the time (interferon ± ribavirin). The introduction of direct-acting antivirals (DAAs), effective across all genotypes and well tolerated, has changed this perception. In liver and kidney transplants, the outcomes of D+/R− grafts under DAA treatment are very encouraging. However, data on D+/R− pancreatic transplantation remain scarce.
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Scientific reference
Bush, A. J., et al. (2025). Emerging strategies in the transplantation of HCV-infected pancreases to uninfected recipients: A narrative review. Transplantation reviews (Orlando, Fla.), 39(4), 100941. Advance online publication
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