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Parkinson’s disease: could it all start in the gut?
26 mai 2025
#Parkinson #Microbiota #Dysbiosis
#Neurogastroenterology #GutHealth #Neuroinflammation
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects approximately 1% of people over the age of 60. It manifests with motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. However, non-motor symptoms such as constipation, sleep disturbances, mood changes, and cognitive issues suggest that more than just the central nervous system is involved. These observations have led to the hypothesis that Parkinson’s may originate in the gut.
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects approximately 1% of people over the age of 60. It manifests with motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. However, non-motor symptoms such as constipation, sleep disturbances, mood changes, and cognitive issues suggest that more than just the central nervous system is involved. These observations have led to the hypothesis that Parkinson’s may originate in the gut.
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Scientific reference
Nishiwaki, H., et al. (2024). Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease. npj Parkinson's Disease, 10(1), 106
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