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When miRNAs take the lead
12 mai 2025
#Asthma #miRNA #Metabolome #Inflammation
#BronchialObstruction
Childhood asthma is a chronic inflammatory disease of the airways, characterized by variable airflow obstruction, airway hyperresponsiveness (AHR), and eosinophilic inflammation. This condition, whose severity and symptoms vary widely between individuals, is one of the leading causes of pediatric respiratory morbidity worldwide. Despite progress in the classification of clinical phenotypes and the availability of therapeutic options, the molecular mechanisms underlying the heterogeneity of the disease remain poorly understood.
Childhood asthma is a chronic inflammatory disease of the airways, characterized by variable airflow obstruction, airway hyperresponsiveness (AHR), and eosinophilic inflammation. This condition, whose severity and symptoms vary widely between individuals, is one of the leading causes of pediatric respiratory morbidity worldwide. Despite progress in the classification of clinical phenotypes and the availability of therapeutic options, the molecular mechanisms underlying the heterogeneity of the disease remain poorly understood.
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Scientific reference
Sharma, R., et al. (2025). miRNAome-metabolome wide association study reveals effects of miRNA regulation in eosinophilia and airflow obstruction in childhood asthma. EBioMedicine, 112
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