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Reprogramming fat to starve the tumor?
23 juillet 2025
By Lila Rouland | Published on July 23, 2025 | 3 min read
#Cancer #Adipocytes #TumorMetabolism #InnovativeTherapy
Cancer cells thrive in a microenvironment that is poor in oxygen and nutrients. To survive, they reprogram their metabolism to more efficiently absorb glucose (aerobic glycolysis, or the Warburg effect) and fatty acids (fatty acid oxidation, or FAO), enabling rapid proliferation.
In a groundbreaking strategy, researchers propose the transplantation of engineered adipose tissue (Adipose Manipulated Tissue, or AMT) to create “metabolic competition” within the tumor microenvironment. The goal? Force adipocytes to consume glucose and lipids so rapidly that the tumor can no longer access them. The results, published in Nature Biotechnology, are striking.
#Cancer #Adipocytes #TumorMetabolism #InnovativeTherapy
Cancer cells thrive in a microenvironment that is poor in oxygen and nutrients. To survive, they reprogram their metabolism to more efficiently absorb glucose (aerobic glycolysis, or the Warburg effect) and fatty acids (fatty acid oxidation, or FAO), enabling rapid proliferation.
In a groundbreaking strategy, researchers propose the transplantation of engineered adipose tissue (Adipose Manipulated Tissue, or AMT) to create “metabolic competition” within the tumor microenvironment. The goal? Force adipocytes to consume glucose and lipids so rapidly that the tumor can no longer access them. The results, published in Nature Biotechnology, are striking.
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Scientific reference
Nguyen H. P. et al. (2024). Implantation of engineered adipocytes suppresses tumor progression in cancer models, Nature Biotechnology.
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