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Sepsis & homocysteine: a biomarker under influence?
6 mai 2025
#Sepsis #Homocysteine #Biomarker #Mortality
#PersonalizedMedicine #IntensiveCare
Sepsis is an exacerbated systemic inflammatory response triggered by infection, leading to acute organ dysfunction. It remains one of the leading causes of death in hospital settings. Despite advancements in early diagnosis, resuscitation protocols, and antimicrobial treatments, short-term mortality remains high, reaching up to 30% in severe cases. Current treatments are primarily symptomatic and standardized, with limited ability to identify high-risk patients or tailor the immune response on an individual basis.
Sepsis is an exacerbated systemic inflammatory response triggered by infection, leading to acute organ dysfunction. It remains one of the leading causes of death in hospital settings. Despite advancements in early diagnosis, resuscitation protocols, and antimicrobial treatments, short-term mortality remains high, reaching up to 30% in severe cases. Current treatments are primarily symptomatic and standardized, with limited ability to identify high-risk patients or tailor the immune response on an individual basis.
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Scientific reference
Lu, X., et al. (2025). The association of plasma homocysteine levels with short-term mortality in sepsis patients: A meta-analysis. Biomolecules and Biomedicine
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