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sFas: a new warning signal in kidney disease?
2 avril 2026
By Ana Espino | Published on April 2, 2026 | 2 min readKidney dysfunction, whether acute (AKI) or chronic (CKD), represents a major public health issue. It is characterized by the progressive accumulation of uremic solutes and persistent systemic inflammation—two closely linked mechanisms involved in disease progression and the development of complications, particularly cardiovascular ones. Curren
Kidney dysfunction, whether acute (AKI) or chronic (CKD), represents a major public health issue. It is characterized by the progressive accumulation of uremic solutes and persistent systemic inflammation—two closely linked mechanisms involved in disease progression and the development of complications, particularly cardiovascular ones.
Current diagnostic tools, especially serum creatinine, remain insufficient to capture the complexity of the underlying mechanisms. They fail to fully integrate the interplay between inflammation, apoptosis, and cellular dysfunction, which are central to renal pathophysiology.
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Scientific reference
Silva BM, et al. Exploring the retention of soluble Fas protein in kidney dysfunction and its link to inflammation: a systematic review and meta-analysis. J Bras Nefrol. 2026 Apr-Jun;48(2):e20250146. doi: 10.1590/2175-8239-JBN-2025-0146en.
