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Gonadotoxic therapies: does the uterus retain lasting damage?
11 septembre 2025
By Ana Espino | Published on september 11, 2025 | 3 min read
#Fertility #Gynecology #Chemotherapy #Endocrinology
Gonadotoxic treatments administered during childhood, adolescence, or young adulthood are well recognized for their detrimental impact on ovarian function and female fertility. While ovarian damage has been widely documented, the effects on the uterus—particularly on uterine volume—remain less studied, despite its crucial role in fertility and pregnancy outcomes. This knowledge gap currently limits the ability to fully assess the reproductive potential of women who survived pediatric or young adult cancers.
#Fertility #Gynecology #Chemotherapy #Endocrinology
Gonadotoxic treatments administered during childhood, adolescence, or young adulthood are well recognized for their detrimental impact on ovarian function and female fertility. While ovarian damage has been widely documented, the effects on the uterus—particularly on uterine volume—remain less studied, despite its crucial role in fertility and pregnancy outcomes. This knowledge gap currently limits the ability to fully assess the reproductive potential of women who survived pediatric or young adult cancers.
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Scientific reference
Fraison, E., et al. (2025). Uterine volume assay after gonadotoxic therapies in childhood, adolescence, and young adulthood: A systematic review and Bayesian network meta-analysis. Acta obstetricia et gynecologica Scandinavica, 104(9), 1616–1626
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