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A race against time for a vaccine?
24 avril 2025
#PfSPZ #Vaccination #Malaria #Immunogenicity
In 2023, malaria affected more than 263 million people worldwide and caused nearly 600,000 deaths, according to the WHO. These alarming numbers have remained almost unchanged over the past decade, illustrating the stagnation of global efforts to eliminate this parasitic disease, despite massive investments. While the development of malaria vaccines marks undeniable scientific progress, their impact remains largely insufficient. For instance, the RTS,S/AS01 and R21/Matrix-M vaccines, although effective against severe forms in young children, have limitations: their protection against infection is low, it wanes quickly, requires multiple doses, and shows little efficacy in adults. These shortcomings significantly limit their potential in eradication strategies and highlight the need for more effective solutions.
In 2023, malaria affected more than 263 million people worldwide and caused nearly 600,000 deaths, according to the WHO. These alarming numbers have remained almost unchanged over the past decade, illustrating the stagnation of global efforts to eliminate this parasitic disease, despite massive investments. While the development of malaria vaccines marks undeniable scientific progress, their impact remains largely insufficient. For instance, the RTS,S/AS01 and R21/Matrix-M vaccines, although effective against severe forms in young children, have limitations: their protection against infection is low, it wanes quickly, requires multiple doses, and shows little efficacy in adults. These shortcomings significantly limit their potential in eradication strategies and highlight the need for more effective solutions.
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Scientific reference
Berry, A. A., et al. (2025). Safety, tolerability and immunogenicity of a condensed, multi-dose prime regimen of PfSPZ Vaccine for the prevention of Plasmodium falciparum malaria infection. Malaria journal, 24(1), 88.
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