Toward the Identification of a Novel Therapeutic Target for Obesity and Steatohepatitis

Obesity and metabolic diseases, notably type 2 diabetes and liver steatosis-associated conditions, represent significant public health concerns. Growth differentiation factor 15 (GDF-15) is a circulating factor primarily involved in the activation of neurons within the brain that regulate food intake. GDF-15 levels in the bloodstream are dysregulated across various disease states, including obesity; however, the molecular pathways governing GDF-15 modulation in obesity and steatohepatitis remain to be elucidated.