HIV and Innate Immunity: How Early Responses Shape the Evolution of Viral Reservoirs

HIV infection remains a significant challenge in the field of infectious diseases, particularly due to the persistence of viral reservoirs, even under antiretroviral therapy (ART). Reservoir cells, which harbor intact proviruses, are the main obstacle to eradicating the virus. Recently, the role of innate immunity in the selection and evolution of reservoir cells has garnered increasing interest, especially during the early initiation of ART. This study investigates these early mechanisms and their implications for HIV control.  

Understanding the Dynamics of Viral Reservoirs