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Virus & fertility: when does the barrier break down?
8 juillet 2025
#Virus #BTB #SertoliCells #ViralInfertility
Long considered an immune-privileged site, the testes are now recognized as a silent yet favored target of several emerging viruses, including Zika, HIV, Ebola and Marburg viruses, and mumps virus. Recent evidence shows that these viral infections can have significant clinical consequences, ranging from fertility disorders to chronic testicular inflammation and even prolonged sexual transmission of the virus.
Long considered an immune-privileged site, the testes are now recognized as a silent yet favored target of several emerging viruses, including Zika, HIV, Ebola and Marburg viruses, and mumps virus. Recent evidence shows that these viral infections can have significant clinical consequences, ranging from fertility disorders to chronic testicular inflammation and even prolonged sexual transmission of the virus.
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Scientific reference
Hager-Soto, E. E., et al. (2025). Viral Disruption of Blood-Testis Barrier Precedes Testicular Infection. Viruses, 17(6), 747
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