Press reviews
2025-11-20
Prostatectomy or SBRT: which treatment better preserves quality of life?
Urology-nephrology Oncology
In men with localized prostate cancer at low or intermediate risk, two curative treatments are now standard options: radical prostatectomy and stereotactic body radiotherapy (SBRT). While surgery is often regarded as the more radical approach, radiotherapy is considered less invasive, but its side effects—particularly bo...
The digital rectal exam (DRE) has historically been a key tool in the early detection of prostate cancer (PCa). Before the widespread use of prostate-specific antigen (PSA) testing, DRE was the primary method for identifying potentially aggressive tumors. PSA transformed early detection by identifying cancers even in asy...
2025-11-19
Oncology
Metastatic castration-resistant prostate cancer (mCRPC) represents an advanced stage of the disease, commonly treated with androgen deprivation therapy (ADT). Although this strategy improves survival, it often leads to a deterioration in quality of life (QoL), with side effects such as fatigue, cognitive impairment, bone...
2025-11-18
Oncology
Metastatic castration-resistant prostate cancer (mCRPC) remains an incurable disease despite a decade of significant therapeutic progress. The clinical objective is no longer limited to survival, but now also includes quality of life (QoL) and symptom control. The biological heterogeneity of mCRPC, marked by increasing g...
2025-11-17
Treatment of prostate cancer with GnRH agonists: what is the real impact on quality of life?
Urology-nephrology Oncology
Prostate cancer is one of the most common cancers in men. In advanced stages, treatment often relies on hormone therapy using GnRH (gonadotropin-releasing hormone) agonists. While this approach slows tumor progression by suppressing testosterone, it also causes significant side effects that may impair quality of life (QoL...
The emergence of immunotherapies, particularly immune checkpoint inhibitors (ICIs), has revolutionized the management of many cancers. However, only a minority of patients derive durable benefit. Current biomarkers such as PD-L1 expression, tumor mutational burden (TMB), and microsatellite instability (MSI) have significa...
2025-11-13
Oncology
Metastatic castration-sensitive prostate cancer (mCSPC) remains a major public health challenge for men worldwide. Historically, its management relied on androgen deprivation therapy (ADT) alone. However, advances in understanding the androgen receptor (AR) signaling pathway have profoundly changed therapeutic strategies...
2025-11-12
Darolutamide: Will it redefine the initial treatment strategy in metastatic prostate cancer?
Oncology
For many years, metastatic castration-sensitive prostate cancer (mCSPC) was treated exclusively with androgen deprivation therapy (ADT). However, recent therapeutic advances have led to the emergence of combination strategies, particularly those involving androgen receptor signaling inhibitors (ARSi). Among these agents,...
2025-11-12
Darolutamide, undetectable PSA, and prolonged survival: a new standard in prostate cancer treatment?
Oncology
Metastatic hormone-sensitive prostate cancer (mHSPC) is undergoing a therapeutic revolution with the introduction of intensified combination regimens incorporating darolutamide.
The ARASENS study, which demonstrated a survival benefit with the addition of darolutamide to androgen deprivation therapy (ADT) and doc...
2025-11-10
Oncology
Metastatic hormone-sensitive prostate cancer (mHSPC) is a clinical entity in which combination therapies have significantly improved overall survival. However, despite these advances, interindividual variability in treatment response remains high, making it difficult to identify patients at high risk of progression.
Metastatic hormone-sensitive prostate cancer (mHSPC) represents a major therapeutic challenge, particularly in older patients who are frequently underrepresented in clinical trials due to comorbidities, physiological frailty, or concerns about increased adverse effects. Yet, over 65% of prostate cancer–related deaths occu...
A recent study published in Nature has revealed a surprising and hopeful connection between COVID-19 mRNA vaccines and improved survival outcomes in patients with certain types of cancer. The research, which focused on individuals undergoing immunotherapy for melanoma and non-small-cell lung cancer, found that those who re...
Localized (non-metastatic) prostate cancer affects a large male population and generally carries a good prognosis. However, patients remain at elevated risk of all-cause mortality, often due to comorbidities such as cardiovascular disease.
Diet is known to influence the course of many chronic illnesses, but its...
Prostate cancer is the second most common cancer in men worldwide. Its incidence varies greatly depending on geography, ethnicity, and, most importantly, lifestyle factors, particularly diet. This review explores how fats, proteins, carbohydrates, vitamins, and phytonutrients influence the development and progre...
2025-11-05
Do vitamins protect against or promote prostate cancer? a matter of source and dosage
Oncology
Prostate cancer (PCa) is the fifth leading cause of cancer-related death among men worldwide. While traditional risk factors (age, ethnicity, metabolic syndrome) are well established, the role of vitamins in prostate cancer prevention remains controversial. Some studies suggest a protective effect, while others indicate a...