Press reviews
2026-04-16
Influenza: a recombinant vaccine improves immune response in patients with severe obesity
Infectiology
A major viral infection, seasonal influenza is responsible each year for severe complications and hospitalizations, particularly among vulnerable populations. Among them, people living with severe obesity (defined as a BMI ≥ 35 kg/m²) represent a high-risk group that remains insufficiently characterized in vaccine trials....
Dementia encompasses a range of progressive cognitive disorders affecting memory, reasoning, and independence. It represents a major public health challenge in the context of global population aging.
While biological and environmental risk factors such as age, comorbidities, and level of education ar...
2026-04-14
Gut–microbiome dialogue: the unexpected role of epithelial cells
Gastroenterology and Hepatology
Interactions between the gut and the intestinal microbiome are essential for proper physiological function. These interactions largely rely on the immune system, which regulates the coexistence between the host and microbial communities.
However, these mechanisms remain poorly understood during early life,...
2026-04-13
Dietary fiber and the microbiome: a key duo still impaired in celiac disease
Gastroenterology and Hepatology
Celiac disease is an autoimmune condition triggered by gluten ingestion, leading to chronic inflammation of the small intestine. This damage alters the intestinal mucosa and impairs nutrient absorption. The only treatment is a strict gluten-free diet, which generally controls symptoms but does not fully restore intestina...
Allergies to domestic animals—particularly cats, dogs, and horses—are a major cause of allergic rhinitis and asthma, especially in children. Exposure to allergens is frequent and widespread, even in the absence of direct contact with animals, due to passive transfer mechanisms.
Diagnostic strategies mainl...
2026-04-10
Vitamin D and the microbiome: toward immune reprogramming in ibd
Gastroenterology and Hepatology
Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, affect millions of patients worldwide. These conditions are characterized by chronic inflammation of the gastrointestinal tract, partly driven by an inappropriate immune response directed against normally tolerated intestinal bacteria.
Multiple sclerosis (MS) is a chronic and disabling neurological disease characterized by an immune-mediated attack on the central nervous system (CNS). This autoimmune response primarily targets myelin, a protective sheath essential for proper nerve impulse conduction.
At the root of this dysregulation is the immune...
Parkinson’s disease is a chronic neurodegenerative disorder characterized by the progressive worsening of motor symptoms. As the disease advances, a large majority of patients treated with levodopa develop motor fluctuations, marked by unpredictable alternations between “ON” and “OFF” periods. These fluctuations lead to signif...
Parkinson’s disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons and the accumulation of protein aggregates. Despite therapeutic advances, the underlying molecular mechanisms remain only partially understood.
The protein LRRK2 (leucine-rich repeat kinase 2) is now rec...
Parkinson’s disease is a major progressive neurodegenerative disorder affecting more than 8.5 million people worldwide. Its incidence continues to rise, making it an increasing public health concern. The disease is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra, along with the accu...
2026-04-03
Gut microbiota: metabolites at the heart of cardiovascular risk
Cardiology and Vascular Medicine Gastroenterology and Hepatology
Coronary heart disease remains the leading cause of mortality worldwide. Its development relies on a complex interplay of genetic, metabolic, and environmental factors. Among these, the role of the gut microbiota has attracted growing interest. Acting as a true metabolic organ, it produces a wide range of molecules capable of...
2026-04-03
Breast cancer: circulating tumor DNA, a key biomarker to anticipate relapse
Oncology Medical Biology
Breast cancer remains the most common cancer among women worldwide. Despite major therapeutic advances, particularly in early-stage disease, the risk of recurrence remains a central challenge in patient management. This risk varies according to tumor subtypes, especially in aggressive forms such as triple-negative or hormone r...
Parental vaccine hesitancy remains a major public health challenge in France, despite the extension of mandatory childhood vaccinations since 2018. Vaccination coverage remains insufficient and marked by persistent delays, maintaining a non-negligible risk of epidemic resurgence.
Traditional information-based strategi...
Kidney dysfunction, whether acute (AKI) or chronic (CKD), represents a major public health issue. It is characterized by the progressive accumulation of uremic solutes and persistent systemic inflammation—two closely linked mechanisms involved in disease progression and the development of complications, particularly cardiovasc...
Shiga toxin-producing Escherichia coli (STEC) infections are the leading cause of hemolytic uremic syndrome (HUS) in children. This severe complication combines hemolytic anemia, thrombocytopenia, and acute kidney failure, and can sometimes be life-threatening.
Despite structured surveillance, identifyin...