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2024-02-27

Nanoparticles to boost the efficacy of anti-arthrosic drugs

Rhumatology

The development of disease-modifying therapies for osteoarthritis involves a number of challenges, including efficient administration and pharmacokinetics. The unique structure of the joint promotes rapid elimination of drugs into the synovial fluid, and the dense, avascular cartilaginous extracellular matrix limits drug penetration. In this work, the researchers demonstrate the feasibility and interest of poly(lactide-co-glycolic acid) nanoparticles coated with chondrocyte membranes. When tested on rat models, these nanoparticles were better absorbed than uncoated nanoparticles. These nanoparticles were internalized by endocytosis. In rats, they restored walking ability, reduced periarticular bone remodelling and provided chondroprotection.

Source(s) :
Ronghui Deng et al. Chondrocyte membrane-coated nanoparticles promote drug retention and halt cartilage damage in rat and canine osteoarthritis. Sci Transl Med. 2024 Feb 21;16(735):eadh9751. ;

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