Nanoparticles to boost the efficacy of anti-arthrosic drugs

The development of disease-modifying therapies for osteoarthritis involves a number of challenges, including efficient administration and pharmacokinetics. The unique structure of the joint promotes rapid elimination of drugs into the synovial fluid, and the dense, avascular cartilaginous extracellular matrix limits drug penetration. In this work, the researchers demonstrate the feasibility and interest of poly(lactide-co-glycolic acid) nanoparticles coated with chondrocyte membranes. When tested on rat models, these nanoparticles were better absorbed than uncoated nanoparticles. These nanoparticles were internalized by endocytosis. In rats, they restored walking ability, reduced periarticular bone remodelling and provided chondroprotection.