NK cell dysfunction in acute HIV infection

Here, researchers studied the timing of NK cell dysfunction during acute HIV infection, and the impact of early initiation of antiretroviral therapy. Data were collected on HIV-infected patients (all men who have sex with men, mean age 26) and HIV-uninfected participants. The proportions of adaptive NK cells increased at the time of HIV diagnosis at all Fiebig stages and were not altered by early initiation of antiretroviral therapy. Proportions of activated HLA-DR+/CD38+ NK cells remained high despite early initiation of antiretroviral therapy.