Staging Alzheimer's disease

The staging of Alzheimer's disease is crucial to its neuropathological diagnosis. Recent advances in molecular imaging have opened the way to in vivo staging of the disease. In this review, the researchers present the current state of knowledge on the staging of Alzheimer's disease. They present current knowledge and the value of staging for better understanding disease mechanisms, refining inclusion criteria for clinical trials of disease-modifying therapies, and facilitating decision-making in anti-amyloid therapies. The researchers describe known biomarkers and the prospects offered by recently identified biomarkers.