Does maternal antiviral prophylaxis impact mother-to-child transmission of hepatitis B virus in real life? Researchers analyzed data on maternal HBV screening, neonatal immunization and post-vaccination serologic testing in at-risk infants born to HBV-positive mothers. A total of 2,460,218 deliveries with maternal HBV status were screened. Among the 22,859 at-risk infants who received antiviral prophylaxis, mother-to-child transmission rates differed between infants born to HBs+/HBe- and HBe+ mothers. Overall, annual Hbe and Hbs seropositivity rates decreased between 2008 and 2022.
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