Similarities and differences between osteoarthritis and rheumatoid arthritis: insights from Mendelian randomization and transcriptome analysis

Osteoarthritis and rheumatoid arthritis are often difficult to distinguish at an early stage of the disease.

The authors first performed a correlation analysis of phenotypic data from genome-wide association studies, arthrosis and rheumatoid arthritis. They then proceeded to the functional enrichment and pathways of genes differentially expressed in patients with osteoarthritis, rheumatoid arthritis and in normal patients. The infiltration of immune cells into arthritis was analyzed according to gene expression.