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Colorectal cancer: why do treatments stop working?
10 mars 2026
By Ana Espino | Published on March 10, 2026 | 3 min readColorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, despite major advances in surgery, chemotherapy, and targeted therapies. Improvements in diagnostic strategies and the introduction of modern therapeutic combinations have increased survival, particularly in metastatic disease. However, these gain
By Ana Espino | Published on March 10, 2026 | 3 min read
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, despite major advances in surgery, chemotherapy, and targeted therapies. Improvements in diagnostic strategies and the introduction of modern therapeutic combinations have increased survival, particularly in metastatic disease. However, these gains are undermined by the almost inevitable emergence of therapeutic resistance, which leads to relapse and tumor progression.
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, despite major advances in surgery, chemotherapy, and targeted therapies. Improvements in diagnostic strategies and the introduction of modern therapeutic combinations have increased survival, particularly in metastatic disease. However, these gains are undermined by the almost inevitable emergence of therapeutic resistance, which leads to relapse and tumor progression.
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Scientific reference
Haynes J, et al. Mechanisms and Strategies to Overcome Drug Resistance in Colorectal Cancer. Int J Mol Sci. 2025 Feb 25;26(5):1988. doi: 10.3390/ijms26051988. PMID: 40076613; PMCID: PMC11901061
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