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Childhood dementia: synaptic hyperactivity as an early trigger in a brain in decline
23 avril 2026
By Elodie Vaz | Published on Avril 23, 2026 | 3 min readSanfilippo syndrome, a common form of childhood dementia, is a rare genetic disease characterized by progressive and fatal neurodegeneration. Affected children initially develop normally before rapidly losing cognitive abilities, language, and motor skills. Early clinical signs—hyperactivity, sleep disturbances, erratic behavior—precede an in
By Elodie Vaz | Published on Avril 23, 2026
| 3 min read
Sanfilippo syndrome, a common form of childhood dementia, is a rare genetic disease characterized by progressive and fatal neurodegeneration. Affected children initially develop normally before rapidly losing cognitive abilities, language, and motor skills. Early clinical signs—hyperactivity, sleep disturbances, erratic behavior—precede an inexorable decline. In Australia, around 1,400 children are affected, and hundreds of thousands of cases are reported worldwide. Behind these numbers are deeply disrupted family lives. “It’s like grieving the life of your child before it has even begun,” said Tenille Koistinen, mother of an affected child, in a press release.
Sanfilippo syndrome, a common form of childhood dementia, is a rare genetic disease characterized by progressive and fatal neurodegeneration. Affected children initially develop normally before rapidly losing cognitive abilities, language, and motor skills. Early clinical signs—hyperactivity, sleep disturbances, erratic behavior—precede an inexorable decline. In Australia, around 1,400 children are affected, and hundreds of thousands of cases are reported worldwide. Behind these numbers are deeply disrupted family lives. “It’s like grieving the life of your child before it has even begun,” said Tenille Koistinen, mother of an affected child, in a press release.
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Scientific reference
Modélisation des dysfonctions synaptiques dans la démence infantile à l’aide de réseaux corticaux dérivés de l’iPSC humain
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