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Glioblastoma: testosterone could slow tumor progression in men
19 mai 2026
By Elodie Vaz | Published on May 19,
2026 | 4 min read
A study conducted by researchers at Cleveland Clinic offers unexpected insight into the interactions between male hormones and brain cancer. Published on May 6 in the journal Nature, the work shows that androgens, particularly testosterone, could limit the growth of glioblastoma in men, contradicting the long-standing dominant hypothesis that these hormones promote the disease.
Glioblastoma is the most common and most aggressive form of primary brain tumor in adults. This cancer is associated with a very poor prognosis despite therapeutic advances. It affects men more often than women, an epidemiological observation that has led many researchers to suspect that male hormones play a harmful role in tumor progression.
A study conducted by researchers at Cleveland Clinic offers unexpected insight into the interactions between male hormones and brain cancer. Published on May 6 in the journal Nature, the work shows that androgens, particularly testosterone, could limit the growth of glioblastoma in men, contradicting the long-standing dominant hypothesis that these hormones promote the disease.
Glioblastoma is the most common and most aggressive form of primary brain tumor in adults. This cancer is associated with a very poor prognosis despite therapeutic advances. It affects men more often than women, an epidemiological observation that has led many researchers to suspect that male hormones play a harmful role in tumor progression.
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Scientific reference
Lee, J., Chung, YM., Silver, D.J. et al. Androgen loss accelerates brain tumour growth via HPA axis activation. Nature (2026). https://doi.org/10.1038/s41586-026-10451-5
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