This content is in French.
MicroRNAs & Microbiota: An Inflammatory Duo?
14 février 2025
#MicroRNA #Microbiota #IBD #Immunotherapy #Innovation
Chronic inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, are characterized by persistent inflammation of the digestive tract, associated with an imbalance in the gut microbiota. This dysbiosis, combined with an exacerbated immune response, contributes to the chronicity of symptoms and complicates patient management.
Recent research suggests that fecal microRNAs (miRNAs), particularly let-7b and miR-21, may play a central role in regulating interactions between the host and its gut microbiota. These small regulatory molecules, known for their involvement in inflammatory and immune processes, are thought to directly influence the composition and activity of the gut microbiota. However, the precise mechanisms by which let-7b and miR-21 modulate microbial balance and intestinal inflammation remain largely unknown.
Chronic inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, are characterized by persistent inflammation of the digestive tract, associated with an imbalance in the gut microbiota. This dysbiosis, combined with an exacerbated immune response, contributes to the chronicity of symptoms and complicates patient management.
Recent research suggests that fecal microRNAs (miRNAs), particularly let-7b and miR-21, may play a central role in regulating interactions between the host and its gut microbiota. These small regulatory molecules, known for their involvement in inflammatory and immune processes, are thought to directly influence the composition and activity of the gut microbiota. However, the precise mechanisms by which let-7b and miR-21 modulate microbial balance and intestinal inflammation remain largely unknown.
Sign in to read the rest
Reserved for healthcare professionals, free registration.
Scientific reference
Casado-Bedmar, et al. (2024). Fecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation. Gut Microbes, 16(1), 2394249
View the source
