Single-cell epigenomic rewiring in alzheimer’s disease progression and cognitive resilience

#Alzheimer #CognitiveResilience


Alzheimer’s disease (AD) remains the leading cause of dementia, characterized by progressive memory loss and neuronal degeneration. While the accumulation of amyloid plaques and tau tangles is well established, the epigenetic mechanisms underlying neuronal vulnerability and resilience are still poorly understood.

In this landmark study, researchers created a single-cell multi-omic atlas of 3.5 million cells from 384 post-mortem brain samples, covering six brain regions from 111 individuals with and without AD.