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TNBC: could everything be happening in the mitochondria?
21 octobre 2025
By Ana Espino | Published on October 21, 2025 | 4 min readTriple-negative breast cancer (TNBC) is a particularly aggressive form of cancer, characterized by the absence of hormone receptors (ER/PR) and HER2. It primarily affects younger women, progresses rapidly, and carries a high risk of relapse, especially due to the lack of exploitable therapeutic targets. Currently, chemotherapy remains the s
By Ana Espino | Published on October 21, 2025 | 4 min read
Triple-negative breast cancer (TNBC) is a particularly aggressive form of cancer, characterized by the absence of hormone receptors (ER/PR) and HER2. It primarily affects younger women, progresses rapidly, and carries a high risk of relapse, especially due to the lack of exploitable therapeutic targets. Currently, chemotherapy remains the standard treatment, but it has major limitations: variable efficacy, significant toxicity, and frequent development of resistance.
In light of this therapeutic dead end, mechanisms of mitochondrial quality control — such as fission, fusion, mitophagy, and biogenesis — are emerging as promising new areas of exploration. These processes, essential for cell survival, are often hijacked by tumor cells to resist stress and sustain their growth.
Triple-negative breast cancer (TNBC) is a particularly aggressive form of cancer, characterized by the absence of hormone receptors (ER/PR) and HER2. It primarily affects younger women, progresses rapidly, and carries a high risk of relapse, especially due to the lack of exploitable therapeutic targets. Currently, chemotherapy remains the standard treatment, but it has major limitations: variable efficacy, significant toxicity, and frequent development of resistance.
In light of this therapeutic dead end, mechanisms of mitochondrial quality control — such as fission, fusion, mitophagy, and biogenesis — are emerging as promising new areas of exploration. These processes, essential for cell survival, are often hijacked by tumor cells to resist stress and sustain their growth.
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Scientific reference
Pei, W., et al. (2025). Targeting Mitochondrial Quality Control for the Treatment of Triple-Negative Breast Cancer: From Molecular Mechanisms to Precision Therapy. Biomolecules, 15(7), 970
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