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Vitamin D and skin: friendly or hostile light?
15 mai 2025
#VitaminD #SkinCancers #UVB #Photoprotection
#PreventiveDermatology
Skin cancer is among the most common cancers worldwide. The most widespread forms are basal cell and squamous cell carcinomas, closely associated with chronic exposure to ultraviolet radiation. This link with UV rays, however, raises a paradox. Vitamin D3, synthesized by the skin under the effect of UVB rays, has anti-inflammatory, antioxidant, and antiproliferative properties, potentially protective against carcinogenesis. Yet its production depends on sun exposure, which is widely recognized for its harmful effects on DNA and its role in the development of skin cancers.
Skin cancer is among the most common cancers worldwide. The most widespread forms are basal cell and squamous cell carcinomas, closely associated with chronic exposure to ultraviolet radiation. This link with UV rays, however, raises a paradox. Vitamin D3, synthesized by the skin under the effect of UVB rays, has anti-inflammatory, antioxidant, and antiproliferative properties, potentially protective against carcinogenesis. Yet its production depends on sun exposure, which is widely recognized for its harmful effects on DNA and its role in the development of skin cancers.
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Scientific reference
Uçar, N., & Holick, M. F. (2025). Illuminating the Connection: Cutaneous Vitamin D3 Synthesis and Its Role in Skin Cancer Prevention. Nutrients, 17(3), 386
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