Chronic endometritis and recurrent reproductive failure: a systematic review and meta-analysis

A population of 1,038 women was included. With regard to the association between chronic endometritis and infertility, a positive correlation was found, with a rate of chronic endometritis of 19.46% in infertile women compared with 7.7% in controls (OR: 2.96, 95% CI 1.53-5.72, p 0.001). No significant association was observed between recurrent implantation failure and chronic endometritis (OR: 1.10, 95% CI 0.26-4.61, p 0.90), and the rates of chronic endometritis in the two groups were relatively comparable, with 6.35% in women with recurrent implantation failure and 5.8% in controls.

In contrast, a strong association between chronic endometritis and recurrent pregnancy loss was found, reporting a chronic endometritis rate of 37.6% in cases of recurrent pregnancy loss versus 16.4% in controls (OR: 3.59, 95% CI 2.46-5.24, p < 0.00001).

Conclusions: chronic endometritis appears to be associated with infertility and recurrent pregnancy loss, whereas no significant association was noted in cases of recurrent implantation failure.